Synthesis and Pharmacochemistry of New Pleiotropic

Synthesis and Pharmacochemistry of New Pleiotropic Pyrrolyl Derivatives.

Within the framework of our attempts to synthesize pleiotropic anti-inflammatory agents, we have synthesized some chalcones and their corresponding 3,4-pyrrolyl derivatives. Chalcones constitute a class of compounds with high biological impact. They are known for a number of biological activities, including anti-inflammatory and free radical scavenging activities. They inhibit several enzymes i...

Role of Cytokines in Pathophysiology of Asthma

The worldwide incidence, morbidity and mortality of asthma are increasing dramatically. It is one of the most common disorders encountered in clinical medicine in both children and adults. It affects approximately 5% of the adult population in the western world and its reported incidence is increasing vigorously in many developed nations. A network of a novel mediator known as ‘pleiotropic cyto...

Narcotic antagonists: naltrexone pharmacochemistry and sustained-release preparations.

QTL mapping of heading date and plant height in Barley cross “Azumamugi”דKanto Nakate Gold

To identify quantitative trait loci (QTLs) controlling heading date and plant height, ninety nine F13 recombinant inbred lines (RILs) derived from barley cultivars Azumamugi × Kanto Nakate Gold cross were evaluated. The field trails were conducted at randomized complete block design with two and three replications in 2004 and 2005, respectively. Significant differences and transgrassive segrega...

A Novel and Efficient Synthesis of New Dixanthones

The facile and high yield synthesis of a new series of dibenzophenones in the presence of polyphosphoric acid (PPA) together with their cyclization to corresponding moni and dixanthones are described. The aromatic nucleophilic substitution of these new compounds are also studied.